HLA-C antibody
-
- Target See all HLA-C Antibodies
- HLA-C (Major Histocompatibility Complex Class I C (HLA-C))
-
Reactivity
- Human, Mouse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This HLA-C antibody is un-conjugated
-
Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human HLA-C
- Isotype
- IgG
- Top Product
- Discover our top product HLA-C Primary Antibody
-
-
- Application Notes
- WB 1:500 - 1:2000
- Restrictions
- For Research Use only
-
- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- HLA-C (Major Histocompatibility Complex Class I C (HLA-C))
- Alternative Name
- HLA-C (HLA-C Products)
- Synonyms
- D6S204 antibody, HLA-JY3 antibody, HLC-C antibody, PSORS1 antibody, major histocompatibility complex, class I, C antibody, HLA-C antibody
- Background
-
Synonyms: 1C07,Cw-7 alpha chain,D6S204,HLA class I histocompatibility antigen,HLA class I histocompatibility antigen, C alpha chain,HLA class I histocompatibility antigen, Cw-1 alpha chain,HLA-C,HLA-C histocompatibility type,HLA-Cw,HLA-JY3,HLAC,HLC-C,human leukocyte antigen-C alpha chain,major histocompatibility antigen HLA-C,major histocompatibility complex, class I, C ,MHC class I antigen,MHC class I antigen Cw 1,MHC class I antigen Cw*7,MHC class I antigen heavy chain HLA-C,PSORS1
Background: HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
- Molecular Weight
-
Observed_MW: 41kDa
Calculated_MW: 41kDa
- Gene ID
- 3107
- UniProt
- P10321
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
-