GCK antibody
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- Target See all GCK Antibodies
- GCK (Glucokinase (Hexokinase 4) (GCK))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GCK antibody is un-conjugated
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Application
- Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human GCK
- Isotype
- IgG
- Top Product
- Discover our top product GCK Primary Antibody
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- Application Notes
- IF 1:20 - 1:100
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- GCK (Glucokinase (Hexokinase 4) (GCK))
- Alternative Name
- GCK (GCK Products)
- Synonyms
- FGQTL3 antibody, GK antibody, GLK antibody, HHF3 antibody, HK4 antibody, HKIV antibody, HXKP antibody, LGLK antibody, MODY2 antibody, Gk antibody, Gls006 antibody, GCK antibody, BA4487 antibody, glk antibody, hk4 antibody, hhf3 antibody, hkiv antibody, hxkp antibody, gck-A antibody, mody2 antibody, glucokinase antibody, GLUKA antibody, RNGK2 antibody, glucokinase antibody, glucokinase (hexokinase 4) L homeolog antibody, glucokinase (hexokinase 4) antibody, GCK antibody, Gck antibody, glcK antibody, Bphyt_1025 antibody, Halhy_6548 antibody, gk antibody, gck.L antibody, gck antibody
- Background
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Synonyms: ATP:D-hexose 6-phosphotransferase,FGQTL3,GCK,GK,GLK,Glucokinase,Hexokinase D pancreatic isozyme,Hexokinase type IV,Hexokinase-4,Hexokinase-D,HHF3,HK IV,HK4,HKIV,HXK4,HXKP,LGLK,MODY2
Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
- Molecular Weight
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Calculated_MW: 52kDa
- Gene ID
- 2645
- UniProt
- P35557
- Pathways
- MAPK Signaling, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process
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