MAT1A antibody (N-Term)

Catalog No. ABIN656632

Product Details anti-MAT1A Antibody

Target: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Binding Specificity: AA 107-136, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAT1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MAT1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human MAT1A.

Clone: RB32086

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: MAT1A Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-MAT1A antibody (ABIN656632)

Bing, Zhu, Yu, Li, Liu, Li, Wang, Qi, Guo, Yuan, He, Liu, Liu: "Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells." in: The Journal of biological chemistry, Vol. 289, Issue 47, pp. 32639-55, (2014) (PubMed).

Geillinger, Rathmann, Köhrle, Fiamoncini, Daniel, Kipp: "Hepatic metabolite profiles in mice with a suboptimal selenium status." in: The Journal of nutritional biochemistry, Vol. 25, Issue 9, pp. 914-22, (2014) (PubMed).

Target Details for MAT1A

Target: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Alternative Name: MAT1A (MAT1A Products)

Background: This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.

Molecular Weight: 43648

Gene ID: 4143

NCBI Accession: NP_000420

UniProt: Q00266

Pathways: Mitotic G1-G1/S Phases, M Phase, Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process