PDP antibody (AA 308-336)

Catalog No. ABIN656386

Product Details anti-PDP Antibody

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Binding Specificity: AA 308-336

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.

Clone: RB31327

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: PDP1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-PDP antibody (ABIN656386)

Shan, Kang, Elf, Xie, Gu, Aguiar, Lonning, Hitosugi, Chung, Arellano, Khoury, Shin, Khuri, Boggon, Fan: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." in: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).

Target Details for PDP

Target: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Alternative Name: PDP1 (PDP Products)

Synonyms: 153332_at antibody, CG12151 antibody, Dmel\\CG12151 antibody, PDP antibody, pdp antibody, PDH antibody, PDPC antibody, PPM2C antibody, Gm1024 antibody, Ppm2c antibody, im:7157162 antibody, zgc:174908 antibody, pdp1 antibody, ppm2c antibody, Pyruvate dehydrogenase phosphatase antibody, pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial antibody, pyruvate dehyrogenase phosphatase catalytic subunit 1 antibody, pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog antibody, Pdp antibody, LOC413080 antibody, PDP1 antibody, Pdp1 antibody, pdp1 antibody, pdp1.L antibody

Background: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 61054

Gene ID: 54704

NCBI Accession: NP_001155251, NP_001155252, NP_001155253, NP_060914

UniProt: Q9P0J1