This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ZNF146 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-45 amino acids from the N-terminal region of human ZNF146.
The ZNF146 protein is a 33 kDa Kruppel protein, composed solely of 10 zinc finger motifs. ZNF146 overexpression in tumours may alter the balance between hRap1 and other telomeric proteins, therefore ZNF146 function may be linked to telomere regulation. ZNF146 is strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. ZNF146 is overexpresseed in 80 % of colorectal cancers.