Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Predicted Reactivity
Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This TOR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 194-221 amino acids from the Central region of human TOR2A.
tor2a antibody, TOR2A antibody, zgc:114110 antibody, TORP1 antibody, Prosalusin antibody, Torsin-2A antibody, torsin family 2 member A antibody, torsin family 2, member A L homeolog antibody, torsin family 2, member A antibody, TOR2A antibody, tor2a.L antibody, tor2a antibody, Tor2a antibody
Background
Salusins are multifunctional bioactive peptides discovered by bioinformatics analyses of a full-length cDNA library. Salusin alpha and salusin beta are related peptides of 28 and 20 amino acids that were recently characterized. These peptides are considered to be biosynthesized from preprosalusin, an alternative-splicing product of the torsion dystonia-related gene (TOR2A), after frameshift reading and digestion at dibasic amino acids. Salusin alpha has recently been shown to be involved in atherosclerosis, it potently suppresses acyl-CoA:cholesterol acyltransferase-1 which stores cholesterol ester converted from free cholesterol in macrophages, thereby reducing human macrophage foam cell formation.