RECQL2 antibody (AA 787-816)

Catalog No. ABIN656017

This Rabbit Polyclonal antibody specifically detects RECQL2 in WB, FACS and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for RECQL2 antibody (AA 787-816) (ABIN656017)

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RECQL2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB17383

Product Details anti-RECQL2 Antibody

Binding Specificity: AA 787-816

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WRN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 787-816 amino acids from the Central region of human WRN.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-RECQL2 antibody (ABIN656017)

Kawakubo-Yasukochi, Morioka, Hazekawa, Yasukochi, Nishinakagawa, Ono, Kawano, Nakamura, Nakashima: "miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment." in: Molecular carcinogenesis, Vol. 57, Issue 2, pp. 295-302, (2018) (PubMed).

Target Details for RECQL2

Target: RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))

Alternative Name: WRN

Background: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.

Molecular Weight: 162461

Gene ID: 7486

NCBI Accession: NP_000544

UniProt: Q14191

Pathways: DNA Damage Repair