KDM3B antibody (AA 869-897)

Catalog No. ABIN656008

Product Details anti-KDM3B Antibody

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Binding Specificity: AA 869-897

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KDM3B antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Predicted Reactivity: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This JHDM2b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 869-897 amino acids from the Central region of human JHDM2b.

Clone: RB14344

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for KDM3B

Target: KDM3B (Lysine (K)-Specific Demethylase 3B (KDM3B))

Alternative Name: JHDM2b (KDM3B Products)

Synonyms: KDM3B antibody, JMJD1B antibody, 5830462I21Rik antibody, JHDM2B antibody, Jmjd1b antibody, mKIAA1082 antibody, 5qNCA antibody, C5orf7 antibody, NET22 antibody, lysine demethylase 3B antibody, lysine (K)-specific demethylase 3B antibody, lysine-specific demethylase 3B antibody, KDM3B lysine (K)-specific demethylase 3B antibody, KDM3B antibody, LOC100540242 antibody, kdm3b antibody, Kdm3b antibody

Background: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

Molecular Weight: 191581

Gene ID: 51780

NCBI Accession: NP_057688

UniProt: Q7LBC6

Pathways: Warburg Effect