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beta Arrestin 1 antibody (C-Term)

ARRB1 Reactivity: Human WB, IF, IHC (p), FACS Host: Rabbit Polyclonal RB31615 unconjugated
Catalog No. ABIN655944
  • Target See all beta Arrestin 1 (ARRB1) Antibodies
    beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
    Binding Specificity
    • 19
    • 11
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 336-363, C-Term
    Reactivity
    • 67
    • 39
    • 25
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 72
    • 10
    • 1
    Rabbit
    Clonality
    • 65
    • 18
    Polyclonal
    Conjugate
    • 53
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This beta Arrestin 1 antibody is un-conjugated
    Application
    • 68
    • 35
    • 32
    • 26
    • 17
    • 14
    • 13
    • 12
    • 9
    • 7
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
    Predicted Reactivity
    B, M, Rb, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ARRB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the C-terminal region of human ARRB1.
    Clone
    RB31615
    Isotype
    Ig Fraction
    Top Product
    Discover our top product ARRB1 Primary Antibody
  • Application Notes
    IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
    Alternative Name
    ARRB1 (ARRB1 Products)
    Background
    Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.
    Molecular Weight
    47066
    Gene ID
    408
    NCBI Accession
    NP_004032, NP_064647
    UniProt
    P49407
    Pathways
    Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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