MNDA antibody (N-Term)

Catalog No. ABIN655190

Product Details anti-MNDA Antibody

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Binding Specificity: AA 26-53, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MNDA antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MNDA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-53 amino acids from the N-terminal region of human MNDA.

Clone: RB23169

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for MNDA

Target: MNDA (Myeloid Cell Nuclear Differentiation Antigen (MNDA))

Alternative Name: MNDA (MNDA Products)

Synonyms: PYHIN3 antibody, A730048F03 antibody, Ifi205b antibody, myeloid cell nuclear differentiation antigen antibody, interferon activated gene 211 antibody, MNDA antibody, Ifi211 antibody

Background: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Molecular Weight: 45836

Gene ID: 4332

NCBI Accession: NP_002423

UniProt: P41218