INHBB antibody (C-Term)

Catalog No. ABIN655083

Product Details anti-INHBB Antibody

Target: INHBB (Inhibin, beta B (INHBB))

Binding Specificity: AA 369-397, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INHBB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, C, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This INHBB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-397 amino acids from the C-terminal region of human INHBB.

Clone: RB23814

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:4000. WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for INHBB

Target: INHBB (Inhibin, beta B (INHBB))

Alternative Name: INHBB (INHBB Products)

Synonyms: actbb antibody, actbetaB antibody, inhibin antibody, inhibin, beta B antibody, inhibin beta B L homeolog antibody, inhibin beta B subunit antibody, inhibin beta B antibody, inhibin beta-B antibody, inhibin beta B chain antibody, inhbb antibody, inhbb.L antibody, INHBB antibody, Inhbb antibody, LOC100719829 antibody

Background: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.

Molecular Weight: 45122

Gene ID: 3625

NCBI Accession: NP_002184

UniProt: P09529

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion