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FBXW8 antibody (AA 270-299)

FBXW8 Reactivity: Human, Mouse WB, FACS, IHC (p) Host: Rabbit Polyclonal RB28550 unconjugated
Catalog No. ABIN654676
  • Target See all FBXW8 Antibodies
    FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))
    Binding Specificity
    • 15
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 270-299
    Reactivity
    • 20
    • 16
    • 8
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse
    Host
    • 34
    • 1
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXW8 antibody is un-conjugated
    Application
    • 34
    • 17
    • 13
    • 13
    • 13
    • 11
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This FBXW8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-299 amino acids from the Central region of human FBXW8.
    Clone
    RB28550
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Wang, Chen, Lin, Li, Zhou, Liu, Logsdon, Jin, Abbruzzese, Tan, Wang: "The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 289, Issue 7, pp. 4009-17, (2014) (PubMed).

  • Target
    FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))
    Alternative Name
    FBXW8 (FBXW8 Products)
    Synonyms
    FBW6 antibody, FBW8 antibody, FBX29 antibody, FBXO29 antibody, FBXW6 antibody, 4930438M06Rik antibody, Fbx29 antibody, F-box and WD repeat domain containing 8 antibody, ring finger protein, transmembrane 2 antibody, F-box and WD-40 domain protein 8 antibody, FBXW8 antibody, Fbxw8 antibody, RNFT2 antibody
    Background
    This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
    Molecular Weight
    67394
    Gene ID
    26259
    NCBI Accession
    NP_036306, NP_699179
    UniProt
    Q8N3Y1
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