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PYM antibody (N-Term)

WIBG Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB28144 unconjugated
Catalog No. ABIN654666
  • Target See all PYM (WIBG) Antibodies
    PYM (WIBG) (Partner of Y14 and mago (WIBG))
    Binding Specificity
    • 7
    • 7
    • 7
    • 2
    • 1
    • 1
    AA 12-40, N-Term
    Reactivity
    • 29
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 27
    • 2
    Rabbit
    Clonality
    • 27
    • 2
    Polyclonal
    Conjugate
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PYM antibody is un-conjugated
    Application
    • 21
    • 15
    • 13
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Predicted Reactivity
    B, M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This WIBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human WIBG.
    Clone
    RB28144
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    PYM (WIBG) (Partner of Y14 and mago (WIBG))
    Alternative Name
    WIBG (WIBG Products)
    Synonyms
    BEST:HL05757 antibody, CG10330 antibody, CG30176 antibody, Dmel\\CG30176 antibody, PYM antibody, Pym antibody, UD3 antibody, A030010B05Rik antibody, zgc:65891 antibody, zgc:77281 antibody, Partner of Y14 and Mago antibody, Wibg protein antibody, PYM homolog 1, exon junction complex associated factor L homeolog antibody, PYM homolog 1, exon junction complex associated factor antibody, Pym antibody, wibg antibody, pym1.L antibody, PYM1 antibody, Pym1 antibody, pym1 antibody
    Background
    Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
    Molecular Weight
    22656
    Gene ID
    84305
    NCBI Accession
    NP_001137325, NP_115721
    UniProt
    Q9BRP8
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