CES2 antibody (AA 340-369)

Catalog No. ABIN654618

Product Details anti-CES2 Antibody

Target: CES2 (Carboxylesterase 2 (CES2))

Binding Specificity: AA 340-369

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CES2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CES2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-369 amino acids from the Central region of human CES2.

Clone: RB18998

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:2000. WB: 1:2000. IHC-P: 1:50~100. FC: 1:25. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CES2 antibody (ABIN654618)

Shang, Liu, Chen, Ning, Xiong, Liu, Mao, Hu, Yang: "Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells." in: Xenobiotica; the fate of foreign compounds in biological systems, pp. 1-13, (2015) (PubMed).

Chen, Wang, Ning, Hu, Liu, Xiong, Wu, Liu, Hu, Yang: "Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1?/Stra13 pathway." in: Xenobiotica; the fate of foreign compounds in biological systems, pp. 1-12, (2015) (PubMed).

Target Details for CES2

Target: CES2 (Carboxylesterase 2 (CES2))

Alternative Name: CES2 (CES2 Products)

Synonyms: CE-2 antibody, CES2A1 antibody, PCE-2 antibody, iCE antibody, Ces2 antibody, im:6908784 antibody, si:dkey-38l12.2 antibody, zgc:153863 antibody, ce-2 antibody, ces2a1 antibody, pce-2 antibody, carboxylesterase 2 antibody, liver carboxylesterase 2 antibody, cocaine esterase antibody, carboxylesterase 2 (intestine, liver) antibody, CES2 antibody, Ces2 antibody, LOC100343300 antibody, LOC100734360 antibody, ces2 antibody

Background: CES2 is a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance.

Molecular Weight: 61807

Gene ID: 8824

NCBI Accession: NP_003860, NP_932327

UniProt: O00748