This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This ABCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-285 amino acids from the Central region of human ABCD1.
ABC42 antibody, ALD antibody, ALDP antibody, AMN antibody, RGD1562128 antibody, zgc:172102 antibody, ABCD1 antibody, Ald antibody, Aldgh antibody, ATP binding cassette subfamily D member 1 antibody, ATP-binding cassette, sub-family D (ALD), member 1 antibody, ATP-binding cassette sub-family D member 1 antibody, ATP binding cassette subfamily D member 1 L homeolog antibody, ABCD1 antibody, Abcd1 antibody, abcd1 antibody, CpipJ_CPIJ013253 antibody, VDBG_05717 antibody, abcd1.L antibody
Background
ABCD1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein is likely involved in the peroxisomal transport or catabolism of very long chain fatty acids. Defects in this gene have been identified as the underlying cause of adrenoleukodystrophy, an X-chromosome recessively inherited demyelinating disorder of the nervous system.