PPP1R14C antibody (C-Term)

Catalog No. ABIN654110

The Rabbit Polyclonal anti-PPP1R14C antibody has been validated for WB and IHC (p). It is suitable to detect PPP1R14C in samples from Human and Mouse. There is 1 publication available.

Quick Overview for PPP1R14C antibody (C-Term) (ABIN654110)

Target: PPP1R14C (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C (PPP1R14C))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R14C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB22524

Product Details anti-PPP1R14C Antibody

Binding Specificity: AA 126-155, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PP1R14C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-155 amino acids from the C-terminal region of human PP1R14C.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PPP1R14C antibody (ABIN654110)

Xiong, Xia, Tang, Pan, Mei, Xiong: "Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response." in: EBioMedicine, Vol. 9, pp. 45-60, (2016) (PubMed).

Target Details for PPP1R14C

Target: PPP1R14C (Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C (PPP1R14C))

Alternative Name: PP1R14C

Background: The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1, see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM].

Molecular Weight: 17843

Gene ID: 81706

NCBI Accession: NP_112211

UniProt: Q8TAE6