GINS1 antibody (N-Term)

Catalog No. ABIN653447

Product Details anti-GINS1 Antibody

Target: GINS1 (GINS Complex Subunit 1 (Psf1 Homolog) (GINS1))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GINS1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GINS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GINS1.

Clone: RB23977

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GINS1 antibody (ABIN653447)

Kang, Farina, Bermudez, Tappin, Du, Galal, Hurwitz: "Interaction between human Ctf4 and the Cdc45/Mcm2-7/GINS (CMG) replicative helicase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 49, pp. 19760-5, (2013) (PubMed).

Kang, Galal, Farina, Tappin, Hurwitz: "Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 16, pp. 6042-7, (2012) (PubMed).

Target Details for GINS1

Target: GINS1 (GINS Complex Subunit 1 (Psf1 Homolog) (GINS1))

Alternative Name: GINS1 (GINS1 Products)

Background: The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4, MIM 610611), Psf1, Psf2 (GINS2, MIM 610609), and Psf3 (GINS3, MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).

Molecular Weight: 22988

Gene ID: 9837

NCBI Accession: NP_066545

UniProt: Q14691

Pathways: DNA Replication, Synthesis of DNA