T-Box 1 antibody (C-Term)

Catalog No. ABIN653331

Product Details anti-T-Box 1 Antibody

Target: T-Box 1 (TBX1)

Binding Specificity: AA 327-356, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 amino acids from the C-terminal region of human TBX1.

Clone: RB22154

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: TBX1 (TBX1 Products)

Synonyms: CAFS antibody, CTHM antibody, DGCR antibody, DGS antibody, DORV antibody, TBX1C antibody, TGA antibody, VCFS antibody, mp:zf637-3-000616 antibody, zgc:136724 antibody, TBX1 antibody, dgs antibody, tga antibody, cafs antibody, cthm antibody, dgcr antibody, dorv antibody, vcfs antibody, tbx1c antibody, xtbx1 antibody, tbx1 antibody, T-box 1 antibody, T-box 1 S homeolog antibody, T-box 1 L homeolog antibody, TBX1 antibody, Tbx1 antibody, tbx1 antibody, tbx1.S antibody, tbx1.L antibody

Background: TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98 % amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 43133

Gene ID: 6899

NCBI Accession: NP_005983, NP_542377, NP_542378

UniProt: O43435

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation