ANGPTL4 antibody (AA 138-167)

Catalog No. ABIN653155

Product Details anti-ANGPTL4 Antibody

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Binding Specificity: AA 138-167

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANGPTL4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ANGPTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the Central region of human ANGPTL4.

Clone: RB18264

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ANGPTL4 antibody (ABIN653155)

Huang, Xie, Lin, Li, Huang, Wang, Ye: "The downregulation of ANGPTL4 inhibits the migration and proliferation of tongue squamous cell carcinoma." in: Archives of oral biology, Vol. 71, pp. 144-149, (2017) (PubMed).

Wan, Wen, Dong, Tang, Liu, Liu, Tao, Gao, Sun, Cao, Fan, Wu: "Establishment of monoclonal HCC cell lines with organ site-specific tropisms." in: BMC cancer, Vol. 15, pp. 678, (2015) (PubMed).

Target Details for ANGPTL4

Target: ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))

Alternative Name: ANGPTL4 (ANGPTL4 Products)

Synonyms: ANGPTL2 antibody, ARP4 antibody, FIAF antibody, HFARP antibody, NL2 antibody, PGAR antibody, pp1158 antibody, Arp4 antibody, Bk89 antibody, Fiaf antibody, Hfarp antibody, Ng27 antibody, Pgar antibody, Pgarg antibody, Pp1158 antibody, ANGPTL4 antibody, fiaf antibody, im:7144703 antibody, si:rp71-39b20.7 antibody, angiopoietin like 4 antibody, angiopoietin-like 4 antibody, ANGPTL4 antibody, Angptl4 antibody, angptl4 antibody

Background: ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This protein is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes.

Molecular Weight: 45214

Gene ID: 51129

NCBI Accession: NP_001034756, NP_647475

UniProt: Q9BY76

Pathways: Regulation of Lipid Metabolism by PPARalpha