FBLN3 antibody (N-Term)

Catalog No. ABIN653039

Product Details anti-FBLN3 Antibody

Target: FBLN3 (Fibulin 3 (FBLN3))

Binding Specificity: AA 119-148, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBLN3 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Pr, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EFEMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the N-terminal region of human EFEMP1.

Clone: RB22140

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-FBLN3 antibody (ABIN653039)

Wang, Cao, Huang, Ke, Luo, Lin, Wang, Zhang, Wang: "EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway." in: Oncotarget, Vol. 6, Issue 16, pp. 14191-208, (2016) (PubMed).

Lin, Wang, Zhu, Li, Xie, Xiang: "Hypertensive vascular remodeling was inhibited by Xuezhikang through the regulation of Fibulin-3 and MMPs in spontaneously hypertensive rats." in: International journal of clinical and experimental medicine, Vol. 8, Issue 2, pp. 2118-27, (2015) (PubMed).

Hu, Gao, Vo, Ke, Pan, Yu, Siegel, Hess, Linskey, Zhou: "Anti-EGFR function of EFEMP1 in glioma cells and patient prognosis." in: Oncoscience, Vol. 1, Issue 3, pp. 205-15, (2015) (PubMed).

Target Details for FBLN3

Target: FBLN3 (Fibulin 3 (FBLN3))

Alternative Name: EFEMP1 (FBLN3 Products)

Synonyms: DHRD antibody, DRAD antibody, FBLN3 antibody, FBNL antibody, FIBL-3 antibody, MLVT antibody, MTLV antibody, S1-5 antibody, T16 antibody, EGF containing fibulin like extracellular matrix protein 1 antibody, EGF-containing fibulin-like extracellular matrix protein 1 antibody, epidermal growth factor-containing fibulin-like extracellular matrix protein 1 antibody, EFEMP1 antibody, Efemp1 antibody

Background: EFEMP1 encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors.

Molecular Weight: 54641

Gene ID: 2202

NCBI Accession: NP_001034437, NP_001034438

UniProt: Q12805

Pathways: EGFR Signaling Pathway