LDLR antibody (AA 391-419)

Catalog No. ABIN2842585

Product Details anti-LDLR Antibody

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Binding Specificity: AA 391-419

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Predicted Reactivity: X, B, Ha, Pig, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LDLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids of human LDLR.

Clone: RB22886

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR (LDLR Products)

Background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place.

Molecular Weight: 95376

Gene ID: 3949

NCBI Accession: NP_000518, NP_001182727, NP_001182728, NP_001182729, NP_001182732

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism