DERL1 antibody (C-Term)

Catalog No. ABIN652693

Product Details anti-DERL1 Antibody

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Binding Specificity: AA 224-251, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DERL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.

Clone: RB22770

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:16000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for DERL1

Target: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Alternative Name: DERL1 (DERL1 Products)

Synonyms: CG10908 antibody, Dmel\\CG10908 antibody, DDBDRAFT_0188135 antibody, DDBDRAFT_0266772 antibody, DDB_0188135 antibody, DDB_0266772 antibody, MGC84200 antibody, wu:fb09d07 antibody, wu:fb94d05 antibody, wu:fj92g12 antibody, zgc:55637 antibody, 1110021N07Rik antibody, AI195141 antibody, AW551338 antibody, Derlin-1 antibody, derlin-1 antibody, DER-1 antibody, DER1 antibody, RGD1311835 antibody, DERLIN-1 antibody, F17A13.150 antibody, F17A13_150 antibody, Derlin-1 antibody, derlin-1 antibody, derlin-1.1 antibody, hypothetical protein antibody, Der1-like domain family, member 1 antibody, derlin 1 antibody, derlin 1 L homeolog antibody, DERLIN-1 antibody, Der-1 antibody, EDI_023440 antibody, PTRG_01331 antibody, derl1 antibody, DERL1 antibody, derl1.L antibody, Derl1 antibody, DER1 antibody

Background: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

Molecular Weight: 28801

Gene ID: 79139

NCBI Accession: NP_001128143, NP_077271

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling