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SREBF1 antibody (AA 349-378)
SREBF1
Reactivity: Human
WB, IHC (p), FACS
Host: Rabbit
Polyclonal
RB21265
unconjugated
Product Details anti-SREBF1 Antibody
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Target
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SREBF1
(Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
Binding Specificity
All epitopes for SREBF1 antibodies
AA 349-378
Reactivity
All reactivities for SREBF1 antibodies
Human
Host
All hosts for SREBF1 antibodies
Rabbit
Clonality
All clonalities for SREBF1 antibodies
Polyclonal
Conjugate
All conjugates for SREBF1 antibodies
This SREBF1 antibody is un-conjugated
Application
All applications for SREBF1 antibodies
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)
Predicted Reactivity
Ha, M, Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SREBF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-378 amino acids of human SREBF1.
Clone
RB21265
Isotype
IgG
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Discover our top product SREBF1 Primary Antibody
Alternatives
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Application Details
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Application Notes
WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date
6 months
Target Details for SREBF1
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Target
SREBF1
(Sterol Regulatory Element Binding Transcription Factor 1 (SREBF1))
Alternative Name
SREBF1 (SREBF1 Products )
Synonyms
SREBP-1c antibody, SREBP1 antibody, bHLHd1 antibody, ADD-1 antibody, ADD1 antibody, D630008H06 antibody, SREBP-1 antibody, SREBP-1a antibody, SREBP1c antibody, Srebp1 antibody, SCREBP1 antibody, SREBP-1C antibody, SREBF1 antibody, srebp1 antibody, sterol regulatory element binding transcription factor 1 antibody, sterol regulatory element binding transcription factor 1 L homeolog antibody, sterol regulatory element binding protein-1 antibody, Sterol regulatory element Binding Protein antibody, SREBF1 antibody, Srebf1 antibody, srebf1.L antibody, SREBP-1 antibody, srebf1 antibody, sbp-1 antibody
Background
SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.
Molecular Weight
121675
Gene ID
6720
NCBI Accession
NP_001005291 , NP_004167
UniProt
P36956
Pathways
AMPK Signaling , Caspase Cascade in Apoptosis , Negative Regulation of Hormone Secretion , Regulation of Lipid Metabolism by PPARalpha
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