C5 antibody (N-Term)

Catalog No. ABIN652518

Product Details anti-C5 Antibody

Target: C5 (Complement Component 5 (C5))

Binding Specificity: AA 253-281, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Specificity: This C5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260~289 amino acids from the N-terminal region of human C5.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This C5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 AA from the N-terminal region of human C5.

Clone: RB21866

Isotype: IgG

Application Details

Application Notes: WB = 1:1000, IHC (p) = 1:50-100, FACS = 1:10-50

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.48 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-C5 antibody (ABIN652518)

Zhang, Huang, Jing, Fu, Yuan, Xia, Cai, Gan, Chen, Zou, Long, Wang, Wang, Xu: "SAK-HV Triggered a Short-period Lipid-lowering Biotherapy Based on the Energy Model of Liver Proliferation via a Novel Pathway." in: Theranostics, Vol. 7, Issue 6, pp. 1749-1769, (2018) (PubMed).

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Alternative Name: C5 (C5 Products)

Synonyms: C5 antibody, LOC565774 antibody, C5a antibody, C5b antibody, CPAMD4 antibody, Hc antibody, RGD1561905 antibody, He antibody, complement C5 antibody, complement component 5 antibody, hemolytic complement antibody, C5 antibody, c5 antibody, Hc antibody

Background: C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
Synonyms: Complement C5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5 beta chain, Complement C5 alpha chain, C5a anaphylatoxin, Complement C5 alpha' chain, CPAMD4, C5

Molecular Weight: 188305 DA

Gene ID: 727

UniProt: P01031

Pathways: Complement System, Carbohydrate Homeostasis