BRSK1 antibody (C-Term)

Catalog No. ABIN652432

Product Details anti-BRSK1 Antibody

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Binding Specificity: AA 654-684, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRSK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BRSK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 654-684 amino acids from the C-terminal region of human BRSK1.

Clone: RB5415

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for BRSK1

Target: BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))

Alternative Name: BRSK1 (BRSK1 Products)

Synonyms: BRSK1 antibody, hSAD1 antibody, Gm1100 antibody, SAD-B antibody, SADB antibody, RGD1563268 antibody, Sad-b antibody, BR serine/threonine kinase 1 antibody, BRSK1 antibody, Brsk1 antibody

Background: BRSK1 may be involved as a checkpoint kinase in the regulation of G2/M arrest in response to UV- or methyl methane sulfonate (MMS)-induced, but not IR-induced, DNA damage. This protein phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. BRSK1 is partitioned between cytoplasmic and nuclear locations in the absence of DNA damage, but translocates to the nucleus in response to Uv- or MMS-induced DNA damage. BRSK1 shares significant homology with the fission yeast Cdr2, a mitosis-regulatory kinase, and Caenorhabditis elegans SAD1, a neuronal cell polarity regulator. The BRSK1 transcript is expressed ubiquitously with the highest levels of expression in brain and testis.

Molecular Weight: 85087

Gene ID: 84446

NCBI Accession: NP_115806

UniProt: Q8TDC3