PAAF1 antibody (N-Term)

Catalog No. ABIN651253

Product Details anti-PAAF1 Antibody

Target: PAAF1 (Proteasomal ATPase-Associated Factor 1 (PAAF1))

Binding Specificity: AA 109-138, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAAF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PAAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from the N-terminal region of human PAAF1.

Clone: RB25789

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PAAF1

Target: PAAF1 (Proteasomal ATPase-Associated Factor 1 (PAAF1))

Alternative Name: PAAF1 (PAAF1 Products)

Synonyms: paaf antibody, rpn14 antibody, wdr71 antibody, WDR71 antibody, MGC146521 antibody, PAAF antibody, Rpn14 antibody, proteasomal ATPase associated factor 1 S homeolog antibody, proteasomal ATPase associated factor 1 antibody, paaf1.S antibody, PAAF1 antibody, paaf1 antibody, Paaf1 antibody

Background: PAAF1 inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency.

Molecular Weight: 42190

Gene ID: 80227

NCBI Accession: NP_001254732, NP_001254733, NP_001254734, NP_001254735, NP_079431

UniProt: Q9BRP4