FOLR2 antibody (AA 18-46)

Catalog No. ABIN651222

Product Details anti-FOLR2 Antibody

Target: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Binding Specificity: AA 18-46

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOLR2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FOLR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids of human FOLR2.

Clone: RB24013

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

References for anti-FOLR2 antibody (ABIN651222)

Puligujja, McMillan, Kendrick, Li, Balkundi, Smith, Veerubhotla, Edagwa, Kabanov, Bronich, Gendelman, Liu: "Macrophage folate receptor-targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution for reduction of human immunodeficiency virus infections." in: Nanomedicine : nanotechnology, biology, and medicine, Vol. 9, Issue 8, pp. 1263-73, (2013) (PubMed).

Target Details for FOLR2

Target: FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))

Alternative Name: FOLR2 (FOLR2 Products)

Synonyms: FOLR2 antibody, BETA-HFR antibody, FBP antibody, FBP/PL-1 antibody, FR-BETA antibody, FR-P3 antibody, FBP2 antibody, Folbp-2 antibody, Folbp2 antibody, folate receptor 1 antibody, folate receptor beta antibody, folate receptor 2 (fetal) antibody, FOLR1 antibody, FOLR2 antibody, Folr2 antibody

Background: FOLR2 is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68 % and 79 % sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.

Molecular Weight: 29280

Gene ID: 2350

NCBI Accession: NP_000794, NP_001107006, NP_001107007, NP_001107008

UniProt: P14207

Pathways: Dicarboxylic Acid Transport