CCR7 antibody (N-Term)

Catalog No. ABIN651190

Product Details anti-CCR7 Antibody

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Binding Specificity: AA 11-37, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR7 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-37 amino acids from the N-terminal region of human CCR7.

Clone: RB21736

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:10~50. WB: 1:500. WB: 1:1000. WB: 1:500-1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CCR7 antibody (ABIN651190)

Berndt, Haverkampf, Reith, Keil, Niggemann, Zänker, Dittmar: "Fusion of CCL21 Non-Migratory Active Breast Epithelial and Breast Cancer Cells Give Rise to CCL21 Migratory Active Tumor Hybrid Cell Lines." in: PLoS ONE, Vol. 8, Issue 5, pp. e63711, (2013) (PubMed).

Target Details for CCR7

Target: CCR7 (Chemokine (C-C Motif) Receptor 7 (CCR7))

Alternative Name: CCR7 (CCR7 Products)

Background: CCR7 is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.

Molecular Weight: 42874

Gene ID: 1236

NCBI Accession: NP_001829

UniProt: P32248

Pathways: Regulation of Actin Filament Polymerization, Positive Regulation of Immune Effector Process