NAT8 antibody (AA 110-138)

Catalog No. ABIN651148

Product Details anti-NAT8 Antibody

Target: NAT8 (N-Acetyltransferase 8 (NAT8))

Binding Specificity: AA 110-138

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAT8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NAT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 110-138 amino acids from the Central region of human NAT8.

Clone: RB25556

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-NAT8 antibody (ABIN651148)

Ding, Dellisanti, Ko, Czajkowski, Puglielli: "The endoplasmic reticulum-based acetyltransferases, ATase1 and ATase2, associate with the oligosaccharyltransferase to acetylate correctly folded polypeptides." in: The Journal of biological chemistry, Vol. 289, Issue 46, pp. 32044-55, (2014) (PubMed).

Ding, Ko, Pehar, Kotch, Peters, Luo, Salamat, Puglielli: "Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ?-secretase (BACE1) levels and A? generation." in: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8424-33, (2012) (PubMed).

Target Details for NAT8

Target: NAT8 (N-Acetyltransferase 8 (NAT8))

Alternative Name: NAT8 (NAT8 Products)

Synonyms: Cml4 antibody, ATase2 antibody, CML1 antibody, GLA antibody, Hcml1 antibody, TSC501 antibody, TSC510 antibody, 0610037O16Rik antibody, N-acetyltransferase 8 antibody, N-acetyltransferase 8 (putative) antibody, N-acetyltransferase 8 (GCN5-related) antibody, Nat8 antibody, NAT8 antibody

Background: This protein, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene.

Molecular Weight: 25619

Gene ID: 9027

NCBI Accession: NP_003951

UniProt: Q9UHE5