Phospholamban antibody (pThr17)

Catalog No. ABIN650834

The Rabbit Polyclonal anti-Phospholamban antibody has been validated for WB and DB. It is suitable to detect Phospholamban in samples from Human and Rat.

Quick Overview for Phospholamban antibody (pThr17) (ABIN650834)

Target: Phospholamban (PLN)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholamban antibody is un-conjugated

Application: Western Blotting (WB), Dot Blot (DB)

Clone: RB24137

Product Details anti-Phospholamban Antibody

Binding Specificity: pThr17

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PLB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T17 of human PLB.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for Phospholamban

Target: Phospholamban (PLN)

Alternative Name: PLB

Background: Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases, whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.

Molecular Weight: 6109

Gene ID: 5350

NCBI Accession: NP_002658

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity