Transportin 1 antibody (N-Term)

Catalog No. ABIN650673

Product Details anti-Transportin 1 Antibody

Target: Transportin 1 (TNPO1)

Binding Specificity: AA 47-74, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transportin 1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TNPO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-74 amino acids from the N-terminal region of human TNPO1.

Clone: RB17873

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-Transportin 1 antibody (ABIN650673)

Conde-Rubio, Mylonas, Widmann: "The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases." in: Cell death discovery, Vol. 7, Issue 1, pp. 164, (2021) (PubMed).

Target Details for Transportin 1

Target: Transportin 1 (TNPO1)

Alternative Name: TNPO1 (TNPO1 Products)

Synonyms: IPO2 antibody, KPNB2 antibody, MIP antibody, MIP1 antibody, TRN antibody, TNPO1 antibody, AU021749 antibody, D13Ertd688e antibody, Kpnb2 antibody, ATTRN1 antibody, F12A24.13 antibody, F12A24_13 antibody, TRANSPORTIN 1 antibody, transportin 1 antibody, DKFZp469O204 antibody, transportin 1 antibody, transportin-1 antibody, transportin 1 S homeolog antibody, TNPO1 antibody, LOC738932 antibody, tnpo1 antibody, Tnpo1 antibody, tnpo1.S antibody, TRN1 antibody

Background: TNPO1 comprises the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins.

Molecular Weight: 102355

Gene ID: 3842

NCBI Accession: NP_002261, NP_694858

UniProt: Q92973

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cellular Glucan Metabolic Process, Protein targeting to Nucleus, CXCR4-mediated Signaling Events