GABARAPL2 antibody

Catalog No. ABIN650659

Product Details anti-GABARAPL2 Antibody

Target: GABARAPL2 (GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GABARAPL2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GABARAPL2 antibody is generated from rabbits immunized with human GABARAPL2 recombinant protein.

Clone: RB22734

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-GABARAPL2 antibody (ABIN650659)

Delaney, Patel, Willis, Haghighiabyaneh, Axelrod, Tancioni, Lu, Bapat, Young, Cadassou, Bartakova, Sheth, Haft, Hui, Saenz, Schlaepfer, Harismendy, Stupack: "Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer." in: Nature communications, Vol. 8, pp. 14423, (2017) (PubMed).

Orfali, ODonovan, Nyhan, Britschgi, Tschan, Cahill, Mongan, Gudas, McKenna: "Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation." in: Experimental hematology, Vol. 43, Issue 9, pp. 781-93.e2, (2015) (PubMed).

Target Details for GABARAPL2

Target: GABARAPL2 (GABA(A) Receptor-Associated Protein-Like 2 (GABARAPL2))

Alternative Name: GABARAPL2 (GABARAPL2 Products)

Synonyms: GABARAPL2 antibody, atg8 antibody, gef2 antibody, gate16 antibody, gate-16 antibody, Gef2 antibody, ATG8 antibody, ATG8C antibody, GATE-16 antibody, GATE16 antibody, GEF-2 antibody, GEF2 antibody, zgc:92319 antibody, 0610012F20Rik antibody, 2900019O08Rik antibody, AI173605 antibody, GABA type A receptor associated protein like 2 antibody, GABA(A) receptor-associated protein like 2 antibody, GABA(A) receptor-associated protein like 2 L homeolog antibody, gamma-aminobutyric acid (GABA) A receptor-associated protein-like 2 antibody, GABARAPL2 antibody, gabarapl2 antibody, Gabarapl2 antibody, gabarapl2.L antibody

Background: Membrane proteins located on vesicles (v-SNAREs) and on the target membrane (t-SNAREs) mediate specific recognition and, possibly, fusion between a transport vesicle and its target membrane. The activity of SNARE molecules is regulated by several soluble cytosolic proteins. We have cloned a bovine brain cDNA encoding a conserved 117 amino acid polypeptide, denoted Golgi-associated ATPase Enhancer of 16 kDa (GATE-16), that functions as a soluble transport factor. GATE-16 interacts with N-ethylmaleimidesensitive factor (NSF) and significantly stimulates its ATPase activity. It also interacts with the Golgi v-SNARE GOS-28 in an NSF-dependent manner. We propose that GATE-16 modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation.

Molecular Weight: 13667

Gene ID: 11345

NCBI Accession: NP_009216

UniProt: P60520

Pathways: Autophagy