USP33 antibody

Catalog No. ABIN636996

Product Details anti-USP33 Antibody

Target: USP33 (Ubiquitin Specific Peptidase 33 (USP33))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP33 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Affinity chromatography purified

Immunogen: USP33 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.

Application Details

Application Notes: IHC-P: 5 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Aliquot and store at -70 °C for long term storage.

Target Details for USP33

Target: USP33 (Ubiquitin Specific Peptidase 33 (USP33))

Alternative Name: USP33 (USP33 Products)

Synonyms: USP33 antibody, VDU1 antibody, 9830169D19Rik antibody, AA409780 antibody, Vdu1 antibody, zgc:77308 antibody, ubiquitin specific peptidase 33 antibody, universal stress protein UspA antibody, Usp33 antibody, USP33 antibody, RR_RS17870 antibody, usp33 antibody

Background: USP 33 is a deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergicreceptor/ADRB2 recycling. It is involved in cell migration via its interaction with intracellular domain of ROBO1, leadingto regulation of Slit signaling. It also plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-proteincoupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2adrenergic receptor (ADRB2).

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling