TYMS antibody
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- Target See all TYMS Antibodies
- TYMS (Thymidylate Synthetase (TYMS))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This TYMS antibody is un-conjugated
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Application
- Immunohistochemistry (IHC)
- Purpose
- Mouse anti-Human Thymidylate Synthase Antibody [IHC only]
- Specificity
- Cytoplasmic
- Purification
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
- Immunogen
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
- Top Product
- Discover our top product TYMS Primary Antibody
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- Application Notes
- Prediluted format : incubate for 30 min at RT (2)
- Restrictions
- For Research Use only
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- Buffer
- Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Target
- TYMS (Thymidylate Synthetase (TYMS))
- Alternative Name
- Thymidylate synthase (TYMS Products)
- Synonyms
- FN1 antibody, ECK2823 antibody, JW2795 antibody, ts antibody, Ts antibody, HST422 antibody, TMS antibody, TS antibody, thymidylate synthetase antibody, contains intron in T4 phage antibody, ThyE antibody, thymidylate synthase antibody, thymidylate synthetase L homeolog antibody, TYMS antibody, thyA antibody, td antibody, thyE antibody, DDA3937_RS04960 antibody, tyms.L antibody, XBJ1_RS15770 antibody, EAMY_RS20680 antibody, Tyms antibody
- Target Type
- Viral Protein
- Background
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Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Gene Symbol: TYMS///TS///OK///SW-cl.29
- Gene ID
- 7298
- UniProt
- P04818
- Pathways
- Mitotic G1-G1/S Phases
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