IGLV1-51 antibody

Catalog No. ABIN6296841

Product Details anti-IGLV1-51 Antibody

Target: IGLV1-51 (Immunoglobulin lambda Variable 1-51 (IGLV1-51))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGLV1-51 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purpose: Mouse anti-Human Lambda Light Chain Antibody Cocktail [IHC only]

Specificity: Cell surface, cytoplasmic and secreted

Purification: Purified human Ig (LcN-2 and ICO-106) was used as the immunogen for this Lambda light chain antibody cocktail.

Immunogen: Purified human Ig (LcN-2 and ICO-106) was used as the immunogen for this Lambda light chain antibody cocktail.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for IGLV1-51

Target: IGLV1-51 (Immunoglobulin lambda Variable 1-51 (IGLV1-51))

Alternative Name: Immunoglobulin lambda variable 1-51 (IGLV1-51 Products)

Synonyms: IGLV151 antibody, V1-19 antibody, immunoglobulin lambda variable 1-51 antibody, IGLV1-51 antibody

Background:

Target Description: This antibody cocktail is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general, the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Lambda light chain antibody is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Gene Symbol: IGLV1-51///IGLC1

Gene ID: 3535

UniProt: P01701, P0CG04