IGKV1D-16 antibody

Catalog No. ABIN6296345

Product Details anti-IGKV1D-16 Antibody

Target: IGKV1D-16 (Immunoglobulin kappa Variable 1D-16 (IGKV1D-16))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGKV1D-16 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purpose: Mouse anti-Human Kappa Light Chain Antibody [IHC only]

Specificity: Cell surface, cytoplasmic and secreted

Purification: Human B-Lymphoma Cells were used as the immunogen for this Kappa light chain antibody.

Immunogen: Human B-Lymphoma Cells were used as the immunogen for this Kappa light chain antibody.

Application Details

Application Notes: Prediluted format : incubate for 30 min at RT (2)

Restrictions: For Research Use only

Handling

Buffer: Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.

Target Details for IGKV1D-16

Target: IGKV1D-16 (Immunoglobulin kappa Variable 1D-16 (IGKV1D-16))

Alternative Name: Immunoglobulin kappa variable 1D-16 (IGKV1D-16 Products)

Synonyms: IGKV1D16 antibody, L15 antibody, L15a antibody, immunoglobulin kappa variable 1D-16 antibody, IGKV1D-16 antibody

Background:

Target Description: This antibody is specific to the kappa light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. In general, the ratio of Kappa to Lambda is 3:1. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the kappa light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

Gene Symbol: IGKV1D-16///IGKC

Gene ID: 3514

UniProt: P01601, P01834