Granulin antibody
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- Target See all Granulin (GRN) Antibodies
- Granulin (GRN)
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Granulin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogen
- Recombinant protein of human GRN
- Isotype
- IgG
- Top Product
- Discover our top product GRN Primary Antibody
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- Application Notes
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WB 1:500 - 1:2000
IHC 1:50 - 1:200 - Comment
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In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines, Present in inflammatory cells and bone marrow, Highest levels in kidney
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20C. Avoid freeze / thaw cycles.
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- Target
- Granulin (GRN)
- Alternative Name
- GRN (GRN Products)
- Synonyms
- GRN antibody, grn antibody, wu:fb11g12 antibody, wu:fj18f05 antibody, MGC53354 antibody, DKFZp459H066 antibody, CLN11 antibody, GEP antibody, GP88 antibody, PCDGF antibody, PEPI antibody, PGRN antibody, epithelin antibody, acrogranin antibody, granulin precursor antibody, granulin a antibody, Granulins antibody, granulin L homeolog antibody, granulin antibody, GRN antibody, grna antibody, grn antibody, grn.L antibody, granulin antibody, ORF1 granulin antibody, Grn antibody
- Target Type
- Viral Protein
- Background
- Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
- Molecular Weight
- 63.544 kDa
- Gene ID
- 2896
- UniProt
- P28799
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