IFI16 antibody

Catalog No. ABIN6291165

Product Details anti-IFI16 Antibody

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFI16 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogen: Recombinant protein of human IFI16

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000
IHC 1:50 - 1:200

Comment:

Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells, Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells, Present in prostate, ovary and breast (at protein level)

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20C. Avoid freeze / thaw cycles.

Target Details for IFI16

Target: IFI16 (Interferon, gamma-Inducible Protein 16 (IFI16))

Alternative Name: IFI16 (IFI16 Products)

Synonyms: IFNGIP1 antibody, PYHIN2 antibody, IFI16 antibody, Ifitm3l antibody, Ifitml antibody, interferon gamma inducible protein 16 antibody, interferon induced transmembrane protein 2 antibody, myeloid cell nuclear differentiation antigen-like protein antibody, interferon-activable protein 203 antibody, IFI16 antibody, Ifitm2 antibody, LOC100156073 antibody, LOC488622 antibody, Ifi16 antibody

Background: This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 88.256 kDa

Gene ID: 3428

UniProt: Q16666

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Autophagy, Inflammasome