ZNF598 antibody (N-Term)

Catalog No. ABIN6266100

Product Details anti-ZNF598 Antibody

Target: ZNF598 (Zinc Finger Protein 598 (ZNF598))

Binding Specificity: N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF598 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: ZFP598 Antibody detects endogenous levels of total ZFP598.

Predicted Reactivity: Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ZFP598, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ZNF598

Target: ZNF598 (Zinc Finger Protein 598 (ZNF598))

Alternative Name: ZNF598 (ZNF598 Products)

Synonyms: ZNF598 antibody, BC023040 antibody, Ntrap antibody, Znf598 antibody, Zfp598 antibody, wu:fc88f12 antibody, zinc finger protein 598 antibody, ZNF598 antibody, znf598 antibody, Zfp598 antibody

Background:

Description: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).

Gene: ZNF598

Molecular Weight: 98 kDa

Gene ID: 90850

UniProt: Q86UK7