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YME1L1 antibody (C-Term)

YME1L1 Reactivity: Human, Mouse, Rat WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6266079
  • Target See all YME1L1 Antibodies
    YME1L1 (YME1-Like 1 (YME1L1))
    Binding Specificity
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    C-Term
    Reactivity
    • 22
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 21
    • 1
    Rabbit
    Clonality
    • 21
    • 1
    Polyclonal
    Conjugate
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    This YME1L1 antibody is un-conjugated
    Application
    • 21
    • 19
    • 18
    • 13
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    YME1L1 Antibody detects endogenous levels of total YME1L1.
    Predicted Reactivity
    Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human YME1L1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product YME1L1 Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    YME1L1 (YME1-Like 1 (YME1L1))
    Alternative Name
    YME1L1 (YME1L1 Products)
    Synonyms
    FtsH1 antibody, Ftsh antibody, FTSH antibody, MEG4 antibody, PAMP antibody, YME1L antibody, YME1-like 1 (S. cerevisiae) antibody, YME1-like 1 ATPase antibody, YME1 like 1 ATPase antibody, Yme1l1 antibody, YME1L1 antibody
    Background

    Description: ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:26923599, PubMed:27786171). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure and mitochondrial protein metabolism (PubMed:18076378, PubMed:26923599, PubMed:27495975). Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins (PubMed:22262461). Required for normal, constitutive degradation of PRELID1 (PubMed:27495975). Catalyzes the degradation of OMA1 in response to membrane depolarization (PubMed:26923599). Required to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1) (PubMed:22262461).

    Gene: YME1L1

    Molecular Weight
    86 kDa
    Gene ID
    10730
    UniProt
    Q96TA2
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