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ULK2 antibody (Internal Region)

ULK2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265890
  • Target See all ULK2 Antibodies
    ULK2 (Unc-51 Like Kinase 2 (ULK2))
    Binding Specificity
    • 11
    • 8
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivity
    Human, Mouse, Rat
    Host
    • 55
    • 9
    Rabbit
    Clonality
    • 56
    • 8
    Polyclonal
    Conjugate
    • 33
    • 7
    • 6
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    This ULK2 antibody is un-conjugated
    Application
    • 48
    • 44
    • 14
    • 11
    • 10
    • 7
    • 5
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificity
    ULK2 Antibody detects endogenous levels of total ULK2.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human ULK2, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product ULK2 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    ULK2 (Unc-51 Like Kinase 2 (ULK2))
    Alternative Name
    ULK2 (ULK2 Products)
    Synonyms
    ULK2 antibody, ATG1B antibody, Unc51.2 antibody, A830085I22Rik antibody, AU015340 antibody, mKIAA0623 antibody, unc-51 like autophagy activating kinase 2 antibody, unc-51 like kinase 2 antibody, ULK2 antibody, Ulk2 antibody, ulk2 antibody
    Background

    Description: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR, however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

    Gene: ULK2

    Molecular Weight
    113kDa
    Gene ID
    9706
    UniProt
    Q8IYT8
    Pathways
    Regulation of Cell Size, Autophagy
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