TSHZ3 antibody (Internal Region)
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- Target See all TSHZ3 Antibodies
- TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))
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Binding Specificity
- Internal Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TSHZ3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- TSH3 Antibody detects endogenous levels of total TSH3.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TSH3, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product TSHZ3 Primary Antibody
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- Application Notes
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))
- Alternative Name
- TSHZ3 (TSHZ3 Products)
- Synonyms
- ZNF537 antibody, A630038G13Rik antibody, Tsh3 antibody, Zfp537 antibody, mKIAA1474 antibody, teashirt3 antibody, TSH3 antibody, teashirt zinc finger homeobox 3 antibody, teashirt zinc finger family member 3 antibody, TSHZ3 antibody, Tshz3 antibody
- Background
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Description: Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter (By similarity). Involved in the modulation of glutamatergic synaptic transmission and long-term synaptic potentiation (By similarity).
Gene: TSHZ3
- Molecular Weight
- 119 kDa
- Gene ID
- 57616
- UniProt
- Q63HK5
- Pathways
- Regulation of Muscle Cell Differentiation
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