TSG101 antibody
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- Target See all TSG101 Antibodies
- TSG101 (Tumor Susceptibility Gene 101 (TSG101))
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Reactivity
- Human, Monkey
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TSG101 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- TSG101 Antibody detects endogenous levels of total TSG101
- Cross-Reactivity
- Human, Monkey
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TSG101
- Isotype
- IgG
- Top Product
- Discover our top product TSG101 Primary Antibody
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- Application Notes
- WB 1:1000-3000, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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- Target
- TSG101 (Tumor Susceptibility Gene 101 (TSG101))
- Alternative Name
- TSG101 (TSG101 Products)
- Background
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Description: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis, the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426).
Gene: TSG101
- Molecular Weight
- 45 kDa
- Gene ID
- 7251
- UniProt
- Q99816
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