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TJP3 antibody (C-Term)

TJP3 Reactivity: Human, Rat, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265590
  • Target See all TJP3 Antibodies
    TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))
    Binding Specificity
    • 10
    • 9
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 30
    • 11
    • 11
    • 1
    Human, Rat, Mouse
    Host
    • 34
    • 2
    Rabbit
    Clonality
    • 35
    • 1
    Polyclonal
    Conjugate
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TJP3 antibody is un-conjugated
    Application
    • 28
    • 16
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificity
    TJP3 Antibody detects endogenous levels of total TJP3.
    Predicted Reactivity
    Pig,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human TJP3, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TJP3 Primary Antibody
  • Application Notes
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))
    Alternative Name
    TJP3 (TJP3 Products)
    Synonyms
    cb766 antibody, wu:fj93c08 antibody, zo-3 antibody, zo3 antibody, ZO-3 antibody, ZO3 antibody, tight junction protein 3 antibody, tight junction protein 3 S homeolog antibody, tjp3 antibody, tjp3.S antibody, TJP3 antibody, Tjp3 antibody
    Background

    Description: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).

    Gene: TJP3

    Molecular Weight
    101 kDa
    Gene ID
    27134
    UniProt
    O95049
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