Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

THOC1 antibody (C-Term)

THOC1 Reactivity: Human, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265557
  • Target See all THOC1 Antibodies
    THOC1 (THO Complex 1 (THOC1))
    Binding Specificity
    • 15
    • 12
    • 9
    • 7
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 77
    • 16
    • 15
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 60
    • 17
    Rabbit
    Clonality
    • 52
    • 25
    Polyclonal
    Conjugate
    • 29
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This THOC1 antibody is un-conjugated
    Application
    • 46
    • 29
    • 14
    • 14
    • 11
    • 9
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    THOC1 Antibody detects endogenous levels of total THOC1.
    Predicted Reactivity
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human THOC1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product THOC1 Primary Antibody
  • Application Notes
    WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    THOC1 (THO Complex 1 (THOC1))
    Alternative Name
    THOC1 (THOC1 Products)
    Synonyms
    p84 antibody, MGC114861 antibody, Tho1 antibody, THOC1 antibody, Hpr1 antibody, HPR1 antibody, P84 antibody, P84N5 antibody, 3110002N20Rik antibody, AW107452 antibody, NMP-84 antibody, LRRGT00070 antibody, THO complex 1 antibody, THO complex 1 protein L homeolog antibody, THO complex subunit 1 antibody, THO complex 1 protein antibody, thoc1 antibody, thoc1.L antibody, THOC1 antibody, LOC100123388 antibody, Thoc1 antibody
    Background

    Description: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation.

    Gene: THOC1

    Molecular Weight
    76 kDa
    Gene ID
    9984
    UniProt
    Q96FV9
You are here:
Support