TDGF1 antibody (Internal Region)

Catalog No. ABIN6265513

Product Details anti-TDGF1 Antibody

Target: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TDGF1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: TDGF1 Antibody detects endogenous levels of total TDGF1.

Predicted Reactivity: Pig,Bovine,Sheep,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TDGF1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for TDGF1

Target: TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))

Alternative Name: TDGF1 (TDGF1 Products)

Synonyms: CR antibody, CRGF antibody, CRIPTO antibody, CR1 antibody, cripto antibody, cb85 antibody, tdgf1 antibody, wu:fe01d04 antibody, zgc:109829 antibody, Cripto-1 antibody, cr1 antibody, cr1a antibody, frl-1 antibody, frl1 antibody, xcr1 antibody, TDGF1 antibody, tdgf3 antibody, cripto-3 antibody, teratocarcinoma-derived growth factor 1 antibody, teratocarcinoma-derived growth factor 1, member 3 L homeolog antibody, teratocarcinoma-derived growth factor 1, member 1 antibody, TDGF1 antibody, Tdgf1 antibody, tdgf1 antibody, tdgf1.3.L antibody, tdgf1.1 antibody

Background:

Description: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).

Gene: TDGF1

Molecular Weight: 21kDa

Gene ID: 6997

UniProt: P13385

Pathways: EGFR Signaling Pathway