SOCS2 antibody

Catalog No. ABIN6265216

Product Details anti-SOCS2 Antibody

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: SOCS2 Antibody detects endogenous levels of total SOCS2

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human SOCS2

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000 IF/ICC 1:200-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C.Stable for 12 months from date of receipt

Expiry Date: 12 months

Target Details for SOCS2

Target: SOCS2 (Suppressor of Cytokine Signaling 2 (SOCS2))

Alternative Name: SOCS2 (SOCS2 Products)

Background:

Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene: SOCS2

Molecular Weight: 23 kDa

Gene ID: 8835

UniProt: O14508

Pathways: JAK-STAT Signaling, Response to Growth Hormone Stimulus