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SGTA antibody (C-Term)

SGTA Reactivity: Human, Mouse, Rat WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6265046
  • Target See all SGTA Antibodies
    SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA))
    Binding Specificity
    • 15
    • 8
    • 7
    • 7
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 36
    • 26
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 48
    • 6
    • 1
    Rabbit
    Clonality
    • 51
    • 4
    Polyclonal
    Conjugate
    • 24
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SGTA antibody is un-conjugated
    Application
    • 46
    • 22
    • 13
    • 13
    • 9
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificity
    SGTA Antibody detects endogenous levels of total SGTA.
    Predicted Reactivity
    Pig,Zebrafish,Bovine,Sheep,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SGTA, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SGTA Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20 °C. Stable for 12 months from date of receipt.
    Expiry Date
    12 months
  • Target
    SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA))
    Alternative Name
    SGTA (SGTA Products)
    Synonyms
    sgta antibody, SGTA antibody, zgc:92462 antibody, SGT antibody, alphaSGT antibody, hSGT antibody, 5330427H01Rik antibody, AI194281 antibody, D10Ertd190e antibody, Sgt antibody, Stg antibody, small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha antibody, small glutamine rich tetratricopeptide repeat containing alpha antibody, small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta antibody, small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha L homeolog antibody, sgta antibody, SGTA antibody, sgtb antibody, sgta.L antibody, Sgta antibody
    Background

    Description: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).

    Gene: SGTA

    Molecular Weight
    34-37 kDa
    Gene ID
    6449
    UniProt
    O43765
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