ARHGAP24 antibody (Internal Region)

Catalog No. ABIN6264735

Product Details anti-ARHGAP24 Antibody

Target: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGAP24 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: RHG24 Antibody detects endogenous levels of total RHG24.

Predicted Reactivity: Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RHG24, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for ARHGAP24

Target: ARHGAP24 (rho GTPase Activating Protein 24 (ARHGAP24))

Alternative Name: ARHGAP24 (ARHGAP24 Products)

Synonyms: FILGAP antibody, RC-GAP72 antibody, RCGAP72 antibody, p73 antibody, p73RhoGAP antibody, 0610025G21Rik antibody, si:ch211-65i12.2 antibody, Rho GTPase activating protein 24 antibody, ARHGAP24 antibody, Arhgap24 antibody, arhgap24 antibody

Background:

Description: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Gene: ARHGAP24

Molecular Weight: 84 kDa

Gene ID: 83478

UniProt: Q8N264

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus