RGS2 antibody (Internal Region)

Catalog No. ABIN6264723

Product Details anti-RGS2 Antibody

Target: RGS2 (Regulator of G-Protein Signaling 2 (RGS2))

Binding Specificity: Internal Region

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: RGS2 Antibody detects endogenous levels of total RGS2.

Predicted Reactivity: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RGS2, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RGS2

Target: RGS2 (Regulator of G-Protein Signaling 2 (RGS2))

Alternative Name: RGS2 (RGS2 Products)

Synonyms: G0S8 antibody, GOS8 antibody, fa96c08 antibody, wu:fa96c08 antibody, wu:fj08f11 antibody, zgc:91965 antibody, g0s8 antibody, regulator of G protein signaling 2 antibody, regulator of G-protein signaling 2 antibody, regulator of G-protein signaling 2, 24kDa antibody, regulator of G-protein signaling 2 L homeolog antibody, RGS2 antibody, Rgs2 antibody, rgs2 antibody, rgs2.L antibody

Background:

Description: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320).

Gene: RGS2

Molecular Weight: 24kDa

Gene ID: 5997

UniProt: P41220

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation